Scientific litterature’s corner

Here is where you’ll find our favorite publications of the month…

N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model

A. Marie, J. Meunier, E. Brun, S. Malmström, V. Baudoux, E. Flaszka, G. Naert, F. Roman, S. Cosnier-Pucheu, S. Gonzalez-Gonzalez – Aging & Disease, 2017


The role of mitochondrial oxidative stress in hearing loss

S. Gonzalez-Gonzalez – Neurological Disorders and Therapeutics, 2017


Senescence-accelerated mouse prone 8 (SAMP8) as a model of age-related hearing loss

A. Marie, P. Larroze-Chicot, S. Cosnier-Pucheu, S. Gonzalez-Gonzalez – Neurosciences Letters, 2017


Previous months:


Innovative pharmaceutical approaches for the management of inner ear disorders

UM Musazzi, S Franzé, F Cilurzo – Drug Delivery and Translational Research, 2017


Biomarkers for Hearing Dysfunction: Facts and Outlook

L Rüttiger, U Zimmermann, M Knipper – ORL, 2017

Transient auditory nerve demyelination as a new mechanism for hidden hearing loss

Guoqiang Wan & Gabriel Corfas, DOI: 10.1038/ncomms14487


Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms

M. Charles Liberman a, b, Sharon G. Kujawa


Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development?

Fei Zheng, Jian Zuo


Cellular Mechanism of noise-induced hearing loss

A. Kurabi et al., Hearing Research, 2 December 2016


Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial

D. R. Freyer et al., The Lancet Oncology, 30 November 2016, DOI:


Auditory Neuropathy – neural and synaptic mechanism

Moser & Starr, Nature Review, March 2016, doi:10.1038/nrneurol.2016.10


A comprehensive map of molecular drug targets

R. Santoset al., Nature Reviews Drug Discovery, 02 December 2016, doi:10.1038/nrd.2016.230



Can Animal Models Contribute to Understanding Tinnitus Heterogeneity in Humans?

Jos J. Eggermont, Frontiers in Aging Neurosciences, REVIEW, 14 November 2016, doi: 10.3389/fnagi.2016.00265


First hearing-disorder drugs stumble Clinical trial failures of two drugs for hearing loss and tinnitus underscore pitfalls for a nascent area of drug development, but lessons learned may help in navigating the uncharted path to approval

K. Kingwell, Nature Reviews Drug Discovery, 3 Nov 2016; doi:10.1038/nrd.2016.222


Glutamate receptor antagonists for tinnitus

Imsuwansri T, et al., Cochrane Database of Systematic Reviews 2016, Issue 10. Art. No.: CD012391, DOI: 10.1002/14651858.CD012391.


Role of antioxidants in prevention of age-related hearing loss: a review of literature

Elham Tavanai E., Mohammadkhani G., November 2016, Eur Arch Otorhinolaryngol, DOI 10.1007/s00405-016-4378-6