CILcare will be attending the Biotech Outsourcing Strategies Event 2018 taking place in Basel
Meet Wahid AWAD, Ph.D. and attend his presentation on June 19th, 2018 from 11 to 12 AM to discover the topic: “assessing compound efficacy in an age-related hearing loss model”.
Dr. Wahid Awad is the Business Development Manager of CILcare. Dr. Awad has more than ten years of professional expertise in the field of Life Sciences. He completed a postdoc in genetics and biotechnology at INRA, France, a Ph.D in genetics from Colorado State University, USA and a master degree in Biotechnology from Wageningen University, Netherlands. With great passion for science and innovation, Dr. Awad was selected a NOVA (top talent community) member in France. Moreover, he was honoured with more than 12 awards in science, research creativity, community service and leadership.
Presentation title: “Assessing compound efficacy in age-related hearing loss model”
Abstract:
Age-related hearing loss (ARHL) is the most common sensory disorder in the elderly population. SAMP8 mouse model presents accelerated senescence and has been identified as a model of gerontological research. SAMP8 displays a progressive age-related decline in brain function associated with a progressive hearing loss mimicking human aging memory deficits and ARHL. The molecular mechanisms associated with SAMP8 senescence process involve oxidative stress leading to chronic inflammation and apoptosis. Here, we studied the effect of N-acetylcysteine (NAC), an antioxidant, on SAMP8 hearing loss and memory to determine the potential interest of this model in the study of new antioxidant therapies. We observed a strong decrease of auditory brainstem response thresholds from 45 to 75 days of age and an increase of distortion product amplitudes from 60 to 75 days in NAC treated group compared to vehicle. Moreover, NAC treated group presented also an increase of memory performance at 60 and 105 days of age. These results confirm that NAC delays the senescence process by slowing the age-related hearing loss, protecting the cochlear hair cells and improving memory, suggesting that antioxidants could be a pharmacological target for age-related hearing and memory loss.
Read CILcare’s publications and scientific journal articles related to inner ear disorders.
Discover more about BOS 2018.
