{"version":"1.0","provider_name":"Cilcare","provider_url":"https:\/\/www.cilcare.com\/jp","title":"inner ear PK studies - Cilcare","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"6hntOQc7En\"><a href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/pk-distribution\/\">\u5185\u8033\u306b\u304a\u3051\u308b\u85ac\u7269\u52d5\u614b\uff08PK\uff09\u8a66\u9a13<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/pk-distribution\/embed\/#?secret=6hntOQc7En\" width=\"600\" height=\"338\" title=\"&#8220;inner ear PK studies&#8221; &#8212; Cilcare\" data-secret=\"6hntOQc7En\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/www.cilcare.com\/wp-includes\/js\/wp-embed.min.js\n<\/script>","description":"inner ear PK studies Whatever the route of administration, the drug candidate for hearing loss or tinnitus has to reach its target, the inner ear, at the desired concentration. Cilcare\u2019s PK studies allow the assessment of the bioavailability of the candidate in the inner ear, to determine its kinetic profile, and to estimate the best time-point and concentration for dosing in a subsequent efficacy study: Route of administration: local (transtympanic, intrabullar, intracochlear, round window niche) and systemic (PO, IP, IV, SC, IM) Kinetics after single (injection or infusion), or repeated administration Samplings: inner ear fluid, tympanic bulla, cerebrospinal fluid (CSF), different brain structures, blood &amp; plasma Bioanalytical data on biological [&hellip;]"}