{"id":10094,"date":"2023-11-09T14:15:03","date_gmt":"2023-11-09T13:15:03","guid":{"rendered":"http:\/\/cilcare.com\/?page_id=10094"},"modified":"2025-05-13T17:58:51","modified_gmt":"2025-05-13T15:58:51","slug":"screening-dose-selection-for-ototoxicity-or-otoprotection","status":"publish","type":"page","link":"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection\/","title":{"rendered":"in vivo models (zebra)"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"10094\" class=\"elementor elementor-10094\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1297866 e-flex e-con-boxed e-con e-parent\" data-id=\"1297866\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a631965 elementor-widget elementor-widget-heading\" data-id=\"a631965\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">IN VIVO \u30e2\u30c7\u30eb<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d8084c7 e-flex e-con-boxed e-con e-parent\" data-id=\"d8084c7\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f53081c elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f53081c\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5b20b60 elementor-widget elementor-widget-heading\" data-id=\"5b20b60\" data-element_type=\"widget\" data-widget_type=\"heading.default\"><div class=\"elementor-widget-container\"><p class=\"translation-block\">\u8074\u899a\u969c\u5bb3\u304a\u3088\u3073\u95a2\u9023\u75be\u60a3\u306e\u5206\u91ce\u306b\u7279\u5316\u3057\u305f\u30b7\u30eb\u30b1\u30a2\u306f\u3001\u81e8\u5e8a\u5fdc\u7528\u3092\u5f37\u304f\u610f\u8b58\u3057\u305f\u524d\u81e8\u5e8a\u7814\u7a76\u5411\u3051\u306b\u3001\u5e45\u5e83\u3044in 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class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3092\u7528\u3044\u305fin vivo\u30a2\u30c3\u30bb\u30a4<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f694281 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f694281\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\">\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u306f\u3001\u8074\u5668\u6bd2\u6027\u8a55\u4fa1\u3001\u8074\u899a\u4fdd\u8b77\u52b9\u679c\u306e\u691c\u8a3c\u3001\u5927\u898f\u6a21\u306a\u5316\u5408\u7269\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u6709\u7528\u306a\u30e2\u30c7\u30eb\u3067\u3059\u3002\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u306f\u3001\u30d2\u30c8\u3068\u306e\u985e\u4f3c\u6027\uff0885\uff05\u4ee5\u4e0a\u306e\u907a\u4f1d\u5b50\u76f8\u540c\u6027\uff09\u3001\u767a\u9054\u306e\u901f\u3055\u3001\u5149\u5b66\u7684\u306a\u900f\u660e\u6027\u306b\u3088\u308a\u3001\u7406\u60f3\u7684\u306a\u30e2\u30c7\u30eb\u751f\u7269\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p><p class=\"translation-block\">\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u306f\u3001\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u306f\u30cb\u30e5\u30fc\u30ed\u30de\u30b9\u30c8\u3068\u547c\u3070\u308c\u308b\u6a5f\u68b0\u611f\u899a\u5668\u3092\u6301\u3063\u3066\u304a\u308a\u300150\u301c200Hz\u306e\u5468\u6ce2\u6570\u3067\u5468\u56f2\u306e\u74b0\u5883\u306e\u632f\u52d5\u3092\u611f\u77e5\u3057\u307e\u3059\u3002\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u30cb\u30e5\u30fc\u30ed\u30de\u30b9\u30c8\u306b\u3042\u308b\u6709\u6bdb\u7d30\u80de\u306f\u3001\u54fa\u4e73\u985e\u306e\u5185\u8033\u6709\u6bdb\u7d30\u80de\u3068\u69cb\u9020\u304a\u3088\u3073\u6a5f\u80fd\u304c\u985e\u4f3c\u3057\u3066\u3044\u307e\u3059\u3002DASPEI\u3067\u67d3\u8272\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u900f\u660e\u306a\u80da\u306e\u4e2d\u3067\u305d\u308c\u3089\u3092 in vivo\u5bb9\u6613\u306b\u89b3\u5bdf\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a03e0c elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"7a03e0c\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\">\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u8a98\u767a\u6027\u8074\u5668\u6bd2\u6027\u306e\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u30e2\u30c7\u30eb\uff1a\n\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u51e6\u7406\u3055\u308c\u305f\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3067\u306f\u3001\u30cb\u30e5\u30fc\u30ed\u30de\u30b9\u30c8\u5185\u306e\u6709\u6bdb\u7d30\u80de\u6570\u306e\u6e1b\u5c11\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3059<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-751b987 elementor-widget elementor-widget-image\" data-id=\"751b987\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"908\" height=\"134\" src=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Zebrafish.png\" class=\"attachment-large size-large wp-image-10102\" alt=\"\" srcset=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Zebrafish.png 908w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Zebrafish-300x44.png 300w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Zebrafish-768x113.png 768w\" sizes=\"(max-width: 908px) 100vw, 908px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09125d1 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"09125d1\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\"><em><strong><a href=\"https:\/\/biobide.com\/portfolio\/ototox-assay\" target=\"_self\">\u30d0\u30a4\u30aa\u30d0\u30a4\u30c9<\/a><\/strong><\/em>\u3068\u306e\u63d0\u643a\u306b\u3088\u308b\u30b5\u30fc\u30d3\u30b9\u63d0\u4f9b<\/p><p class=\"translation-block\"><em><a href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/\" target=\"_self\"><strong>in vitro<\/strong><\/a> <a href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/\" target=\"_self\"><strong>\u30e2\u30c7\u30eb\u304a\u3088\u3073\u8778\u725b\u5916\u690d\u7247\u30e2\u30c7\u30eb\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/strong><\/a><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6e4fac8 e-flex e-con-boxed e-con e-parent\" data-id=\"6e4fac8\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3844f9e elementor-widget elementor-widget-heading\" data-id=\"3844f9e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u3052\u3063\u6b6f\u985e\u304a\u3088\u3073\u5927\u578b\u52d5\u7269<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a334b1e elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"a334b1e\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\">\u5f53\u793e\u306f\u3001\u598a\u5a20\u4e2d\u306e\u96cc\u30de\u30a6\u30b9\u3084\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u3092\u542b\u3080\u3001\u5e45\u5e83\u3044\u3052\u3063\u6b6f\u985e\u304a\u3088\u3073\u5927\u578b\u52d5\u7269\u3092\u7528\u3044\u305f\u7814\u7a76\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>in vivo models Uniquely specialized in the field of hearing disorders and associated diseases, Cilcare provides a comprehensive range of in vivo studies for preclinical research with a strong translational focus. Our dedicated efforts in this field are geared towards driving innovation and progress in the diagnosis and treatment of hearing-related conditions. in vivo assay in Zebrafish Zebrafish provide a valuable model for assessing ototoxicity, evaluating otoprotection, and conducting large-scale compound screenings. Zebrafish produce an ideal model due to their similarities with humans (over 85% of genetic homology), rapid development, and optical transparency. Zebrafish present mechanosensory organs called neuromasts, which detect vibrations in the surrounding environment at frequencies from 50 [&hellip;]<\/p>","protected":false},"author":6,"featured_media":0,"parent":9055,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10094","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>in vivo models (zebra) - Cilcare<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"in vivo models (zebra) - Cilcare\" \/>\n<meta property=\"og:description\" content=\"in vivo models Uniquely specialized in the field of hearing disorders and associated diseases, Cilcare provides a comprehensive range of in vivo studies for preclinical research with a strong translational focus. Our dedicated efforts in this field are geared towards driving innovation and progress in the diagnosis and treatment of hearing-related conditions. in vivo assay in Zebrafish Zebrafish provide a valuable model for assessing ototoxicity, evaluating otoprotection, and conducting large-scale compound screenings. Zebrafish produce an ideal model due to their similarities with humans (over 85% of genetic homology), rapid development, and optical transparency. 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