{"id":10236,"date":"2023-11-13T11:29:17","date_gmt":"2023-11-13T10:29:17","guid":{"rendered":"http:\/\/cilcare.com\/?page_id=10236"},"modified":"2025-02-24T14:53:16","modified_gmt":"2025-02-24T13:53:16","slug":"screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro","status":"publish","type":"page","link":"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/","title":{"rendered":"in vitro \/ ex vivo assays (otic cells)"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"10236\" class=\"elementor elementor-10236\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1297866 e-flex e-con-boxed e-con e-parent\" data-id=\"1297866\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a631965 elementor-widget elementor-widget-heading\" data-id=\"a631965\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">IN VITRO \/ EX VIVO \u30a2\u30c3\u30bb\u30a4<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1310c05 e-flex e-con-boxed e-con e-parent\" data-id=\"1310c05\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef803dc elementor-widget elementor-widget-heading\" data-id=\"ef803dc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u8033\u7d30\u80de\u682a\u3092\u7528\u3044\u305fin vitro\u30a2\u30c3\u30bb\u30a4<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f694281 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f694281\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>\u8074\u899a\u4fdd\u8b77<\/strong><\/h3><p class=\"translation-block\">\u30b7\u30eb\u30b1\u30a2\u306ein vitro\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30e2\u30c7\u30eb\u306f\u3001\u77ed\u671f\u9593\u3067\u5927\u898f\u6a21\u306a\u85ac\u5264\u5019\u88dc\u30e9\u30a4\u30d6\u30e9\u30ea\u306e\u8074\u899a\u4fdd\u8b77\u7279\u6027\u306e\u7814\u7a76\u304a\u3088\u3073\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p><p class=\"translation-block\">\u30a2\u30c3\u30bb\u30a4\u306f\u3001\u30de\u30a6\u30b9\u306e\u30b3\u30eb\u30c1\u5668\u5b98\u304b\u3089\u6d3e\u751f\u3057\u305f\u4e0d\u6b7b\u5316\u7d30\u80de\u682a HEI-OC1 \u304c\u4f7f\u7528\u3055\u308c\u307e\u3059\uff08\u30ab\u30e9\u30a4\u30f3\u3089\u306b\u3088\u3063\u30662003\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u8ad6\u6587\uff09\u3002\u3053\u308c\u3089\u306e\u7d30\u80de\u306f\u521d\u671f\u6bb5\u968e\u306e\u30de\u30a6\u30b9\u8778\u725b\u304b\u3089\u63a1\u53d6\u3055\u308c\u3066\u304a\u308a\u3001\u8778\u725b\u306e\u611f\u899a\u7d30\u80de\u304a\u3088\u3073\u652f\u6301\u7d30\u80de\u306e\u7279\u7570\u7684\u30de\u30fc\u30ab\u30fc\u3092\u767a\u73fe\u3057\u307e\u3059\u3002HEI-OC1\u7d30\u80de\u682a\u306f\u3053\u308c\u307e\u3067250\u4ef6\u4ee5\u4e0a\u306e\u7814\u7a76\u3067\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u5185\u8033\u7814\u7a76\u306b\u304a\u3051\u308b\u53c2\u7167\u7d30\u80de\u682a\u3067\u3059\u3002\u8074\u899a\u7cfb\u306f\u3001\u975e\u5e38\u306b\u8907\u96d1\u306a\u89e3\u5256\u69cb\u9020\u3092\u6301\u3061\u3001\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u304f\u3001\u8907\u6570\u306e\u9aa8\u5c64\u306b\u5305\u307e\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u304a\u3044\u3066\u3053\u306e\u7d30\u80de\u682a\u306f\u975e\u5e38\u306b\u4fa1\u5024\u306e\u3042\u308b\u30c4\u30fc\u30eb\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a03e0c elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"7a03e0c\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>NAC\u306b\u3088\u308b\u8074\u899a\u4fdd\u8b77<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-751b987 elementor-widget elementor-widget-image\" data-id=\"751b987\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"756\" height=\"284\" src=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Otoprotection-with-NAC-1.png\" class=\"attachment-large size-large wp-image-10216\" alt=\"\" srcset=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Otoprotection-with-NAC-1.png 756w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Otoprotection-with-NAC-1-300x113.png 300w\" sizes=\"(max-width: 756px) 100vw, 756px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09125d1 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"09125d1\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\">\u30b7\u30eb\u30b1\u30a2\u306e\u30e2\u30c7\u30eb\u306f\u3001MTT\u30a2\u30c3\u30bb\u30a4\u3068CCK8\u30a2\u30c3\u30bb\u30a4\u306e\u4e21\u65b9\u3067\u3001N-\u30a2\u30bb\u30c1\u30eb\u30b7\u30b9\u30c6\u30a4\u30f3\uff08NAC\uff09\u304c\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u640d\u50b7\u304b\u3089\u4fdd\u8b77\u3059\u308b\u80fd\u529b\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b70945 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5b70945\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>NAC\u306b\u3088\u308b\u7279\u6027\u8a55\u4fa1<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6747339 elementor-widget elementor-widget-image\" data-id=\"6747339\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"756\" height=\"354\" src=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Characterisation-with-NAC-1.png\" class=\"attachment-large size-large wp-image-10217\" alt=\"\" srcset=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Characterisation-with-NAC-1.png 756w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Characterisation-with-NAC-1-300x140.png 300w\" sizes=\"(max-width: 756px) 100vw, 756px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-00936d2 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"00936d2\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\">Cilcare\u306e\u30e2\u30c7\u30eb\u306f\u3001\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u8a98\u767a\u6027\u8074\u5668\u6bd2\u6027\u306b\u304a\u3051\u308bNAC\u306e\u4f5c\u7528\u6a5f\u5e8f\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002NAC\u306f\u3001\u30ab\u30b9\u30d1\u30fc\u30bc\u6d3b\u6027\u5316\u3092\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u90e8\u5206\u7684\u306b\u6291\u5236\u3057\u3001\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306e\u7523\u751f\u3092\u5b8c\u5168\u306b\u6291\u5236\u3057\u307e\u3057\u305f\u3002<\/p><p>\u00a0<\/p><h3><strong>\u8074\u5668\u6bd2\u6027<\/strong><\/h3><p class=\"translation-block\">\u30b7\u30eb\u30b1\u30a2\u306ein vitro\u30e2\u30c7\u30eb\u306f\u3001\u65e9\u671f\u6bb5\u968e\u3067\u6f5c\u5728\u7684\u306a\u8074\u5668\u6bd2\u6027\u5316\u5408\u7269\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306e\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u30a2\u30c3\u30bb\u30a4\u3067\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6594084 e-flex e-con-boxed e-con e-child\" data-id=\"6594084\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d81f19d elementor-widget elementor-widget-image\" data-id=\"d81f19d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"768\" height=\"269\" src=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Cisplatin-ototoxicity-images-768x269.jpg\" class=\"attachment-medium_large size-medium_large wp-image-10098\" alt=\"\" srcset=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Cisplatin-ototoxicity-images-768x269.jpg 768w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Cisplatin-ototoxicity-images-300x105.jpg 300w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Cisplatin-ototoxicity-images-1024x359.jpg 1024w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Cisplatin-ototoxicity-images.jpg 1095w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d6e575 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"6d6e575\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>HEI-OC1\u7d30\u80de\u306b\u304a\u3051\u308b\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u8074\u5668\u6bd2\u6027<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f4dfb53 e-flex e-con-boxed e-con e-parent\" data-id=\"f4dfb53\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-25c7320 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"25c7320\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u306b\u3088\u308b\u7d30\u80de\u4ee3\u8b1d\u304a\u3088\u3073\u5b9a\u91cf\u5316<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e21192 elementor-widget elementor-widget-image\" data-id=\"2e21192\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"343\" src=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Cell-metabolism-and-quantification-with-cisplatin-1-768x343.png\" class=\"attachment-medium_large size-medium_large wp-image-10218\" alt=\"\" srcset=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Cell-metabolism-and-quantification-with-cisplatin-1-768x343.png 768w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Cell-metabolism-and-quantification-with-cisplatin-1-300x134.png 300w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Cell-metabolism-and-quantification-with-cisplatin-1-1024x457.png 1024w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Cell-metabolism-and-quantification-with-cisplatin-1-1536x686.png 1536w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Cell-metabolism-and-quantification-with-cisplatin-1.png 1732w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c6d6230 e-flex e-con-boxed e-con e-parent\" data-id=\"c6d6230\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93637bc elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"93637bc\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\">\u5316\u5408\u7269\u306e\u6f5c\u5728\u7684\u306a\u8074\u5668\u6bd2\u6027\u306f\u3001\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u307e\u305f\u306f\u4ed6\u306e\u53c2\u7167\u3068\u306a\u308b\u8074\u5668\u6bd2\u6027\u85ac\u3068\u6bd4\u8f03\u8a55\u4fa1\u3067\u304d\u307e\u3059\u3002\u30a2\u30cd\u30ad\u30b7\u30f3\u3001\u30ab\u30b9\u30d1\u30fc\u30bc3-7\u304a\u3088\u3073-8\u6d3b\u6027\u3001\u304a\u3088\u3073ROS\u7523\u751f\u306b\u3088\u308b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u95a2\u3059\u308b\u8ffd\u52a0\u306e\u30a2\u30c3\u30bb\u30a4\u3082\u5b9f\u65bd\u3067\u304d\u3001\u85ac\u5264\u5019\u88dc\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u7406\u89e3\u3092\u6df1\u3081\u308b\u305f\u3081\u306e\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u307e\u3059\u3002<\/p><p>\u8074\u899a\u4fdd\u8b77\u304a\u3088\u3073\u8074\u5668\u6bd2\u6027\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u304a\u3051\u308b\u591a\u69d8\u306a\u88dc\u5b8c\u7684\u8a55\u4fa1\u9805\u76ee<\/p><ul><li>\u7d30\u80de\u751f\u5b58\u7387<\/li><li>\u7d30\u80de\u6bd2\u6027<\/li><li>\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u7523\u751f<\/li><li>\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3068\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u306e\u6bd4\u8f03<\/li><li>\u30ab\u30b9\u30d1\u30fc\u30bc3\/7\u306e\u6d3b\u6027\u5316<\/li><li>\u30ab\u30b9\u30d1\u30fc\u30bc8\u306e\u6d3b\u6027\u5316<\/li><li>\u7d30\u80de\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\uff08Ca++\uff09\u5897\u52a0<\/li><li>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd<\/li><li>\u7d30\u80de\u5f62\u614b\u306e\u5909\u5316<\/li><li>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f<\/li><li>\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790<\/li><\/ul><p class=\"translation-block\">\u3053\u306ein vitro\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30e2\u30c7\u30eb\u306f\u3001<strong><a href=\"https:\/\/www.neuro-zone.com\/ototox\" target=\"_self\">Neuro-Zone<\/a><\/strong> \u793e\u3068\u306e\u63d0\u643a\u306b\u3088\u308a\u63d0\u4f9b\u3055\u308c\u307e\u3059\u3002<\/p><p class=\"translation-block\"><em><a href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/\" target=\"_self\"><strong>\u8778\u725b\u5916\u690d\u7247\u30e2\u30c7\u30eb\u304a<\/strong><\/a>\u3088\u3073\u30bc<a href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection\/\" target=\"_self\"><strong>\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u30e2\u30c7\u30eb\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/strong><\/a>.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>in vitro \/ ex vivo assays in vitro assay on otic cell line Otoprotection Cilcare\u2019s in vitro screening model allows the study and screening of the otoprotective properties of a large library of drug candidates in a short timeframe. The assay is performed on the immortalized cell line HEI-OC1 derived from the mouse\u2019s organ of Corti (Kalinec et al., 2003). These cells are taken from early-stage mouse cochleae and express specific markers including those of cochlear sensory cells and supporting cells. Used in more than 250 studies, HEI-OC1 is a reference cell line in inner ear research. They represent a valuable tool for screening since the auditory system has an [&hellip;]<\/p>","protected":false},"author":6,"featured_media":0,"parent":9055,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10236","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>in vitro \/ ex vivo assays (otic cells) - Cilcare<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"in vitro \/ ex vivo assays (otic cells) - Cilcare\" \/>\n<meta property=\"og:description\" content=\"in vitro \/ ex vivo assays in vitro assay on otic cell line Otoprotection Cilcare\u2019s in vitro screening model allows the study and screening of the otoprotective properties of a large library of drug candidates in a short timeframe. The assay is performed on the immortalized cell line HEI-OC1 derived from the mouse\u2019s organ of Corti (Kalinec et al., 2003). These cells are taken from early-stage mouse cochleae and express specific markers including those of cochlear sensory cells and supporting cells. Used in more than 250 studies, HEI-OC1 is a reference cell line in inner ear research. They represent a valuable tool for screening since the auditory system has an [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/\" \/>\n<meta property=\"og:site_name\" content=\"Cilcare\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-24T13:53:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Otoprotection-with-NAC-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"756\" \/>\n\t<meta property=\"og:image:height\" content=\"284\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"3\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/\",\"url\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/\",\"name\":\"in vitro \/ ex vivo assays (otic cells) - Cilcare\",\"isPartOf\":{\"@id\":\"https:\/\/www.cilcare.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Otoprotection-with-NAC-1.png\",\"datePublished\":\"2023-11-13T10:29:17+00:00\",\"dateModified\":\"2025-02-24T13:53:16+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/#primaryimage\",\"url\":\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Otoprotection-with-NAC-1.png\",\"contentUrl\":\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Otoprotection-with-NAC-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.cilcare.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Our missions &#8211; External innovation\",\"item\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"in vitro \/ ex vivo assays (otic cells)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.cilcare.com\/#website\",\"url\":\"https:\/\/www.cilcare.com\/\",\"name\":\"Cilcare\",\"description\":\"Making hearing a priority\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.cilcare.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"in vitro \/ ex vivo assays (otic cells) - Cilcare","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/","og_locale":"ja_JP","og_type":"article","og_title":"in vitro \/ ex vivo assays (otic cells) - Cilcare","og_description":"in vitro \/ ex vivo assays in vitro assay on otic cell line Otoprotection Cilcare\u2019s in vitro screening model allows the study and screening of the otoprotective properties of a large library of drug candidates in a short timeframe. 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