{"id":10238,"date":"2023-11-10T13:13:54","date_gmt":"2023-11-10T12:13:54","guid":{"rendered":"http:\/\/cilcare.com\/?page_id=10238"},"modified":"2025-02-24T14:53:45","modified_gmt":"2025-02-24T13:53:45","slug":"screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo","status":"publish","type":"page","link":"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/","title":{"rendered":"in vitro \/ ex vivo assays (explants)"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"10238\" class=\"elementor elementor-10238\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1297866 e-flex e-con-boxed e-con e-parent\" data-id=\"1297866\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a631965 elementor-widget elementor-widget-heading\" data-id=\"a631965\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">IN VITRO \/ EX VIVO \u30a2\u30c3\u30bb\u30a4<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1310c05 e-flex e-con-boxed e-con e-parent\" data-id=\"1310c05\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef803dc elementor-widget elementor-widget-heading\" data-id=\"ef803dc\" data-element_type=\"widget\" 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vivo\u5b9f\u9a13\u3068\u306e\u6a4b\u6e21\u3057\u3068\u3057\u3066\u975e\u5e38\u306b\u6709\u7528\u3067\u3059\u3002\u5206\u96e2\u3055\u308c\u305f\u8778\u725b\u7d44\u7e54\u306b\u7126\u70b9\u3092\u5f53\u3066\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u85ac\u5264\u5019\u88dc\u3084\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u6709\u52b9\u6027\u304a\u3088\u3073\u4f5c\u7528\u6a5f\u5e8f\u306b\u95a2\u3059\u308b\u91cd\u8981\u306a\u898b\u8b58\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u7dbf\u5bc6\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308a\u3001\u751f\u4f53\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u9032\u3080\u524d\u306b\u3001\u53b3\u5bc6\u306a\u7528\u91cf\u9078\u629e\u3068\u6700\u9069\u5316\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u6700\u7d42\u7684\u306b\u306f\u6642\u9593\u3068\u30ea\u30bd\u30fc\u30b9\u3092\u7bc0\u7d04\u3057\u306a\u304c\u3089\u3001\u8074\u899a\u6a5f\u80fd\u56de\u5fa9\u306e\u6210\u529f\u7387\u5411\u4e0a\u3084\u8074\u5668\u6bd2\u6027\u56de\u907f\u306e\u53ef\u80fd\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u306b\u3082\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a03e0c elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"7a03e0c\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u30e9\u30c3\u30c8\u8778\u725b\u5168\u6458\u6a19\u672c\u306e\u514d\u75ab\u67d3\u8272<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-751b987 elementor-widget elementor-widget-image\" data-id=\"751b987\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"767\" src=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Immunostaining-of-a-cochlear-whole-mount-from-rat-768x767.png\" class=\"attachment-medium_large size-medium_large wp-image-10100\" alt=\"\" srcset=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Immunostaining-of-a-cochlear-whole-mount-from-rat-768x767.png 768w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Immunostaining-of-a-cochlear-whole-mount-from-rat-300x300.png 300w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Immunostaining-of-a-cochlear-whole-mount-from-rat-1024x1024.png 1024w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Immunostaining-of-a-cochlear-whole-mount-from-rat-150x150.png 150w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Immunostaining-of-a-cochlear-whole-mount-from-rat-600x600.png 600w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Immunostaining-of-a-cochlear-whole-mount-from-rat.png 1226w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09125d1 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"09125d1\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p 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class=\"elementor-element elementor-element-6747339 elementor-widget elementor-widget-image\" data-id=\"6747339\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"564\" height=\"618\" src=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Hair-cells-labelled-with-Myosin7a.png\" class=\"attachment-large size-large wp-image-10101\" alt=\"\" srcset=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Hair-cells-labelled-with-Myosin7a.png 564w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Hair-cells-labelled-with-Myosin7a-274x300.png 274w\" sizes=\"(max-width: 564px) 100vw, 564px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-00936d2 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"00936d2\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\"><em><a href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-in-vitro\/\" target=\"_self\"><strong>in vitro<\/strong><\/a> \u30e2\u30c7\u30eb\u304a\u3088\u3073<a href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection\/\" target=\"_self\"><strong>\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u30e2\u30c7\u30eb\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/strong><\/a>.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6594084 e-flex e-con-boxed e-con e-child\" data-id=\"6594084\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e7588b e-flex e-con-boxed e-con e-parent\" data-id=\"5e7588b\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-dcad008 e-con-full e-flex e-con e-child\" data-id=\"dcad008\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-722493e e-con-full e-flex e-con e-child\" data-id=\"722493e\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>in vitro \/ ex vivo assays ex vivo assay on cochlear explants Cochlear explant studies offer a valuable bridge between in vitro investigations and full-scale in vivo experiments. By focusing on isolated cochlear tissue, we gain crucial insight into the efficiency and mechanism of action of drug candidates or gene therapy. This meticulous approach allows for rigorous dose selection and optimization before advancing to live animal models, ultimately saving time and resources while enhancing the prospects of successful auditory restoration or absence of ototoxicity. Immunostaining of a cochlear whole mount from rat Cilcare\u2019s cochlear explant models allow to quantify and qualify damage to crucial cochlear structures, including outer and inner [&hellip;]<\/p>","protected":false},"author":6,"featured_media":0,"parent":9055,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10238","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>in vitro \/ ex vivo assays (explants) - Cilcare<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"in vitro \/ ex vivo assays (explants) - Cilcare\" \/>\n<meta property=\"og:description\" content=\"in vitro \/ ex vivo assays ex vivo assay on cochlear explants Cochlear explant studies offer a valuable bridge between in vitro investigations and full-scale in vivo experiments. By focusing on isolated cochlear tissue, we gain crucial insight into the efficiency and mechanism of action of drug candidates or gene therapy. This meticulous approach allows for rigorous dose selection and optimization before advancing to live animal models, ultimately saving time and resources while enhancing the prospects of successful auditory restoration or absence of ototoxicity. Immunostaining of a cochlear whole mount from rat Cilcare\u2019s cochlear explant models allow to quantify and qualify damage to crucial cochlear structures, including outer and inner [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/\" \/>\n<meta property=\"og:site_name\" content=\"Cilcare\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-24T13:53:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Immunostaining-of-a-cochlear-whole-mount-from-rat-1024x1024.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/\",\"url\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/\",\"name\":\"in vitro \/ ex vivo assays (explants) - Cilcare\",\"isPartOf\":{\"@id\":\"https:\/\/www.cilcare.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Immunostaining-of-a-cochlear-whole-mount-from-rat-768x767.png\",\"datePublished\":\"2023-11-10T12:13:54+00:00\",\"dateModified\":\"2025-02-24T13:53:45+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/#primaryimage\",\"url\":\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Immunostaining-of-a-cochlear-whole-mount-from-rat-768x767.png\",\"contentUrl\":\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/Immunostaining-of-a-cochlear-whole-mount-from-rat-768x767.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.cilcare.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Our missions &#8211; External innovation\",\"item\":\"https:\/\/www.cilcare.com\/our-missions-external-innovation\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"in vitro \/ ex vivo assays (explants)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.cilcare.com\/#website\",\"url\":\"https:\/\/www.cilcare.com\/\",\"name\":\"Cilcare\",\"description\":\"Making hearing a priority\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.cilcare.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"in vitro \/ ex vivo assays (explants) - Cilcare","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/screening-dose-selection-for-ototoxicity-or-otoprotection-ex-vivo\/","og_locale":"ja_JP","og_type":"article","og_title":"in vitro \/ ex vivo assays (explants) - Cilcare","og_description":"in vitro \/ ex vivo assays ex vivo assay on cochlear explants Cochlear explant studies offer a valuable bridge between in vitro investigations and full-scale in vivo experiments. 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