{"id":13339,"date":"2025-02-24T11:42:07","date_gmt":"2025-02-24T10:42:07","guid":{"rendered":"https:\/\/www.cilcare.com\/?page_id=13339"},"modified":"2025-02-24T11:55:05","modified_gmt":"2025-02-24T10:55:05","slug":"vectors-gene-therapies-distribution","status":"publish","type":"page","link":"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/vectors-gene-therapies-distribution\/","title":{"rendered":"vectors &#038; gene therapies distribution"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"13339\" class=\"elementor elementor-13339\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1297866 e-flex e-con-boxed e-con e-parent\" data-id=\"1297866\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div 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class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u30e2\u30eb\u30e2\u30c3\u30c8\u306e\u5185\u8033\u306b\u304a\u3051\u308bAAV\u5c0e\u5165\u306e\u5206\u5e03\uff08\u5148\u7aef\u304b\u3089\u57fa\u5e95\u307e\u3067\uff09<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7867292 elementor-widget elementor-widget-image\" data-id=\"7867292\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"562\" src=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/AAV-distribution-1024x562.png\" class=\"attachment-large size-large wp-image-10536\" alt=\"\" srcset=\"https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/AAV-distribution-1024x562.png 1024w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/AAV-distribution-300x165.png 300w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/AAV-distribution-768x421.png 768w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/AAV-distribution-1536x843.png 1536w, https:\/\/www.cilcare.com\/wp-content\/uploads\/2023\/11\/AAV-distribution-2048x1124.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>vectors &amp; gene therapy distribution As biotherapy experts, we specialize in providing a range of assays to meticulously evaluate the biodistribution of gene therapy vectors, including AAV, and the effectiveness of gene therapy. Assessing the biodistribution of viral vectors in gene therapy research traditionally relies on reporter gene expression, using fluorescent or luminescent signals to identify transduced tissues and cells. However, AAV vectors have limited DNA capacity, hindering the co-expression of therapeutic and reporter genes. Additionally, immune responses to fluorescent proteins like GFP can cause damage, especially in the central nervous system. Relying solely on reporter gene expression assumes equivalent transduction efficiency, which may not be accurate. To address these [&hellip;]<\/p>","protected":false},"author":6,"featured_media":0,"parent":9055,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-13339","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>vectors &amp; gene therapies distribution - Cilcare<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/vectors-gene-therapies-distribution\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"vectors &amp; gene therapies distribution - Cilcare\" \/>\n<meta property=\"og:description\" content=\"vectors &amp; gene therapy distribution As biotherapy experts, we specialize in providing a range of assays to meticulously evaluate the biodistribution of gene therapy vectors, including AAV, and the effectiveness of gene therapy. Assessing the biodistribution of viral vectors in gene therapy research traditionally relies on reporter gene expression, using fluorescent or luminescent signals to identify transduced tissues and cells. However, AAV vectors have limited DNA capacity, hindering the co-expression of therapeutic and reporter genes. Additionally, immune responses to fluorescent proteins like GFP can cause damage, especially in the central nervous system. Relying solely on reporter gene expression assumes equivalent transduction efficiency, which may not be accurate. 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