{"id":12140,"date":"2024-05-21T09:12:23","date_gmt":"2024-05-21T07:12:23","guid":{"rendered":"https:\/\/www.cilcare.com\/?p=12140"},"modified":"2024-05-21T09:29:22","modified_gmt":"2024-05-21T07:29:22","slug":"cilcare-cbsets-review-article-on-ototoxicity-published-in-frontiers-molecular-in-neurosciences","status":"publish","type":"post","link":"https:\/\/www.cilcare.com\/jp\/2024\/05\/21\/cilcare-cbsets-review-article-on-ototoxicity-published-in-frontiers-molecular-in-neurosciences\/","title":{"rendered":"Cilcare-CBSET&#8217;s review article on ototoxicity published in Frontiers in Molecular Neuroscience !"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"12140\" class=\"elementor elementor-12140\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22a8dcc7 e-flex e-con-boxed e-con e-parent\" data-id=\"22a8dcc7\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-793a1fd6 elementor-widget elementor-widget-text-editor\" data-id=\"793a1fd6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>In the intricate realm of drug development, safeguarding auditory function emerges as a paramount concern. The threat of ototoxicity\u2014a condition characterized by drug-induced damage to the ear\u2014poses significant challenges in the pursuit of therapeutic advancements.<\/strong><\/h3><p>In a recent review article published in <strong><a href=\"https:\/\/www.frontiersin.org\/journals\/molecular-neuroscience\"><em>Frontiers in Molecular Neuroscience<\/em><\/a><\/strong> titled &#8220;<strong>Ototoxicity: A High Risk to Auditory Function That Needs to Be Monitored in Drug Development<\/strong>,&#8221; Cilcare &amp; CBSET\u2019s researchers illuminate the pressing need for vigilance in assessing and mitigating ototoxicity during the drug development process.<\/p><p>Edited by <strong><a href=\"https:\/\/www.creighton.edu\/campus-directory\/steyger-peter\">Peter S. Steyger<\/a><\/strong>, Creighton University, US, the publication delves into the multifaceted landscape of ototoxicity, encompassing its intricate mechanism of action, the spectrum of ototoxic drugs, and its profound epidemiological impact. By elucidating the underlying mechanisms through which ototoxic drugs induce damage to the auditory system, the authors underscore the importance of understanding the pathophysiology of drug-induced hearing loss.<\/p><p>Moreover, the article advocates for a comprehensive approach to monitoring ototoxicity during drug development, emphasizing the rationale behind proactive surveillance. With the recognition of ototoxicity as a significant risk factor, stakeholders are urged to integrate advanced screening technologies and predictive models into the development pipeline. These include innovative non-in vivo models such as <strong>organoids<\/strong>, <strong>cell-based assays<\/strong>, and <strong>cochlear explants<\/strong>, which offer valuable insights into drug-induced damage to the auditory system.<\/p><p>Furthermore, this review article underscores the importance of selecting appropriate <strong><em>in vivo<\/em> models<\/strong> for ototoxicity assessment, taking into account species-specific differences in susceptibility to drug-induced hearing loss. By leveraging <strong>ototoxicity biomarkers<\/strong> and implementing robust monitoring protocols throughout the <strong>clinical phases<\/strong>, researchers can effectively identify and mitigate potential risks to auditory health.<\/p><p><em>Read the full article here:<strong> <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2024.1379743\/full\">Link to the Publication<\/a><\/strong><\/em><\/p><p><em>Related ototoxicity services available on <a href=\"https:\/\/www.cilcare.com\/jp\/our-missions-external-innovation\/in-vivo-studies\/#tolerance\"><strong>Cilcare\u2019s<\/strong> <strong>External Innovation section<\/strong><\/a> \u306e\u4e88\u9632\u304a\u3088\u3073\u6cbb\u7642\u3092\u76ee\u7684\u3068\u3057\u305f\u9769\u65b0\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u652f\u63f4\u3057\u3066\u3044\u307e\u3059\u3002 <strong><a href=\"https:\/\/cbset.com\/auditory-safety-services\/\">CBSET auditory safety webpage<\/a><\/strong><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>In the intricate realm of drug development, safeguarding auditory function emerges as a paramount concern. The threat of ototoxicity\u2014a condition characterized by drug-induced damage to the ear\u2014poses significant challenges in the pursuit of therapeutic advancements. In a recent review article published in Frontiers in Molecular Neuroscience titled &#8220;Ototoxicity: A High Risk to Auditory Function That Needs to Be Monitored in Drug Development,&#8221; Cilcare &amp; CBSET\u2019s researchers illuminate the pressing need for vigilance in assessing and mitigating ototoxicity during the drug development process. Edited by Peter S. Steyger, Creighton University, US, the publication delves into the multifaceted landscape of ototoxicity, encompassing its intricate mechanism of action, the spectrum of ototoxic drugs, [&hellip;]<\/p>","protected":false},"author":6,"featured_media":12152,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[110],"tags":[],"class_list":["post-12140","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","entry","has-media"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cilcare-CBSET&#039;s review article on ototoxicity published in Frontiers in Molecular Neuroscience ! - Cilcare<\/title>\n<meta name=\"description\" content=\"Cilcare-CBSET&#039;s review article on ototoxicity published in Frontiers Molecular in Neurosciences !\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cilcare.com\/jp\/2024\/05\/21\/cilcare-cbsets-review-article-on-ototoxicity-published-in-frontiers-molecular-in-neurosciences\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cilcare-CBSET&#039;s review article on ototoxicity published in Frontiers in Molecular Neuroscience ! 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