{"id":3257,"date":"2019-03-04T09:59:23","date_gmt":"2019-03-04T08:59:23","guid":{"rendered":"https:\/\/www.cilcare.com\/?p=3257"},"modified":"2019-03-04T09:59:23","modified_gmt":"2019-03-04T08:59:23","slug":"not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope","status":"publish","type":"post","link":"https:\/\/www.cilcare.com\/jp\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/","title":{"rendered":"World Hearing Day : Not A Single Drug Is Approved to Treat Hearing Loss, but Now There Is Hope"},"content":{"rendered":"

CILcare \/ CBSET Partnership Supports \u201cWorld Hearing Day 2019\u201d<\/a>,<\/h3>\n

Sponsored by the World Health Organization (WHO) on March 3rd<\/sup>, to Make Hearing a Priority<\/h4>\n

\"WorldHearingDay\"<\/a><\/p>\n

 <\/p>\n

1\u00a0 Hearing loss is at epidemic prevalence.<\/h4>\n

According to the National Institutes of Health (NIH), about three out of every 1,000 children<\/strong> in the United States are born with a detectable level of hearing loss in one or both ears. One in eight Americans (30 million) age 12 years or older has hearing loss in both ears. Close to 38 million Americans age 18 and over report some trouble hearing. Worldwide, hearing loss afflicts 466 million people<\/strong>.<\/p>\n

 <\/p>\n

2\u00a0 There are no approved drugs to treat hearing loss.<\/h4>\n

\u201cWhile there are, of course, therapeutics that effectively treat middle-ear infections, there are no drugs that treat the cochlea<\/em>,” says Marie-Pierre Pasdelou, PharmD<\/strong>, Founder and Chief Development Officer of CILcare<\/a>, a leading preclinical contract research organization dedicated to ear disorders. \"synapses\"<\/a><\/p>\n

“The cochlea is a complex sensory organ embedded in one of the most hardened bones of the body,” Dr. Pasdelou explains. \u201cNoise-induced damage to the nearly 16,000<\/a> microscopic hair cells in the cochlea is the primary instigator of Noise-Induced Hearing Loss (NIHL). Delivering drugs to these challenging-to-access cochlear hair cells has been a\u00a0considerable hindrance to hearing loss drug development.\u201d<\/p>\n

 <\/p>\n

3 \u00a0Translational research is advancing potential solutions.<\/h4>\n

\u201cThough great progress is being made toward understanding the genesis of hearing loss, translation of promising fresh approaches into human clinical trials has been sluggish,\u201d explains Rami Tzafriri, PhD<\/strong>, Director of Research and Innovation for CBSET<\/a>, a leading translational research CRO. \u201cThis reflects multifactorial challenges ranging from the need to identify the relevant target populations and safe and efficacious compounds, to the need to better understand and overcome physiological barriers to inner-ear drug delivery, and the relative paucity of expert labs focusing on this disease.\u201d<\/p>\n

 <\/p>\n

4\u00a0 In vivo<\/em> data is very encouraging.<\/h4>\n

\"pharmacokineticscilcare\"\u201cWhile the challenge to develop safe and effective drugs that treat hearing loss continues to be formidable, it is not unconquerable,\u201d adds Celia Belline<\/strong>, CILcare<\/a>\u2019s co-founder and CEO. \u201cIndeed, impressive in vivo<\/em> results are emboldening pharma companies not only to make investments in developing new treatments for hearing loss but also support academia to translate the outcomes of their research into clinical\u00a0benefits.\u201d<\/p>\n

 <\/p>\n

A good example of the scientific progress now being made in developing a safe and efficacious therapy for hearing loss is a study presented recently by CILcare<\/a> at the 42nd Annual MidWinter Meeting of the Association for Research in Otolaryngology (ARO). CILcare scientists reported that the compound \u201cGSK3077978A\u201d, <\/em>a CD38 inhibitor, delayed the ageing process in an accelerated-senescence mouse model (\u201cSAMP8\u201d) and slowed down age-related hearing loss, protecting hearing functions. The results suggest that GSK3077978A\u2019s target could be a potential pharmacological bull\u2019s-eye for age-related hearing loss, which afflicts one in three persons 65 years and older. (<\/em>CD38<\/em><\/strong> is a protein-coding gene. SAMP8 <\/em><\/strong>[Senescence Accelerated Mouse-Prone 8] is a naturally occurring mouse line that displays a phenotype of accelerated aging.)<\/p>\n

\u201cAge-related hearing loss (ARHL) is the most rampant sensory disorder among elderly persons. We are very encouraged by our preclinical results that highlight the CD38 enzyme as a potential pharmacological target for thwarting AHRL,\u201d says CILcare<\/a>\u2019s Chief Scientific Officer, Sylvie Pucheu, PhD<\/strong>.<\/p>\n

\u201cWith GLP-compliant and AAALAC-accredited, state-of-the-art laboratories along with novel expertise, the CBSET and CILcare partnership is strongly positioned to assist drug developers in generating the preclinical safety studies as part of their regulatory application. Without a single marketed drug therapy to restore hearing loss, and an ageing population, the need for therapies is dire and growing. The CBSET \/ CILcare collaboration is empowering us to contribute to the development of promising new drug therapies,\u201d says Peter Markham<\/strong>, President and CEO, CBSET<\/a>. On this year\u2019s World Hearing Day, there is certainly great cause for optimism.\u201d<\/p>\n

 <\/p>","protected":false},"excerpt":{"rendered":"

CILcare \/ CBSET Partnership Supports \u201cWorld Hearing Day 2019\u201d, Sponsored by the World Health Organization (WHO) on March 3rd, to Make Hearing a Priority   1\u00a0 Hearing loss is at epidemic prevalence. According to the National Institutes of Health (NIH), about three out of every 1,000 children in the United States are born with a detectable level of hearing loss in one or both ears. One in eight Americans (30 million) age 12 years or older has hearing loss in both ears. Close to 38 million Americans age 18 and over report some trouble hearing. Worldwide, hearing loss afflicts 466 million people.   2\u00a0 There are no approved drugs to […]<\/p>","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[],"class_list":["post-3257","post","type-post","status-publish","format-standard","hentry","category-events","entry"],"yoast_head":"\nWorld Hearing Day : Not A Single Drug Is Approved to Treat Hearing Loss, but Now There Is Hope - Cilcare<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cilcare.com\/jp\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"World Hearing Day : Not A Single Drug Is Approved to Treat Hearing Loss, but Now There Is Hope - Cilcare\" \/>\n<meta property=\"og:description\" content=\"CILcare \/ CBSET Partnership Supports \u201cWorld Hearing Day 2019\u201d, Sponsored by the World Health Organization (WHO) on March 3rd, to Make Hearing a Priority   1\u00a0 Hearing loss is at epidemic prevalence. According to the National Institutes of Health (NIH), about three out of every 1,000 children in the United States are born with a detectable level of hearing loss in one or both ears. One in eight Americans (30 million) age 12 years or older has hearing loss in both ears. Close to 38 million Americans age 18 and over report some trouble hearing. Worldwide, hearing loss afflicts 466 million people.   2\u00a0 There are no approved drugs to […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cilcare.com\/jp\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/\" \/>\n<meta property=\"og:site_name\" content=\"Cilcare\" \/>\n<meta property=\"article:published_time\" content=\"2019-03-04T08:59:23+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/cilcare.com\/wp-content\/uploads\/2019\/03\/Image1-300x63.png\" \/>\n<meta name=\"author\" content=\"CILcare\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"CILcare\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"3\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/\",\"url\":\"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/\",\"name\":\"World Hearing Day : Not A Single Drug Is Approved to Treat Hearing Loss, but Now There Is Hope - Cilcare\",\"isPartOf\":{\"@id\":\"https:\/\/www.cilcare.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/cilcare.com\/wp-content\/uploads\/2019\/03\/Image1-300x63.png\",\"datePublished\":\"2019-03-04T08:59:23+00:00\",\"author\":{\"@id\":\"https:\/\/www.cilcare.com\/#\/schema\/person\/71c4c9a5956da88e9a9de08ad23b27ac\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/#primaryimage\",\"url\":\"http:\/\/cilcare.com\/wp-content\/uploads\/2019\/03\/Image1-300x63.png\",\"contentUrl\":\"http:\/\/cilcare.com\/wp-content\/uploads\/2019\/03\/Image1-300x63.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.cilcare.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"World Hearing Day : Not A Single Drug Is Approved to Treat Hearing Loss, but Now There Is Hope\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.cilcare.com\/#website\",\"url\":\"https:\/\/www.cilcare.com\/\",\"name\":\"Cilcare\",\"description\":\"Making hearing a priority\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.cilcare.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.cilcare.com\/#\/schema\/person\/71c4c9a5956da88e9a9de08ad23b27ac\",\"name\":\"CILcare\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\/\/www.cilcare.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/4bc8be812ab5693ac188aed8222fa384249de7201f47b7b8db392d1474d732de?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/4bc8be812ab5693ac188aed8222fa384249de7201f47b7b8db392d1474d732de?s=96&d=mm&r=g\",\"caption\":\"CILcare\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"World Hearing Day : Not A Single Drug Is Approved to Treat Hearing Loss, but Now There Is Hope - Cilcare","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cilcare.com\/jp\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/","og_locale":"ja_JP","og_type":"article","og_title":"World Hearing Day : Not A Single Drug Is Approved to Treat Hearing Loss, but Now There Is Hope - Cilcare","og_description":"CILcare \/ CBSET Partnership Supports \u201cWorld Hearing Day 2019\u201d, Sponsored by the World Health Organization (WHO) on March 3rd, to Make Hearing a Priority   1\u00a0 Hearing loss is at epidemic prevalence. According to the National Institutes of Health (NIH), about three out of every 1,000 children in the United States are born with a detectable level of hearing loss in one or both ears. One in eight Americans (30 million) age 12 years or older has hearing loss in both ears. Close to 38 million Americans age 18 and over report some trouble hearing. Worldwide, hearing loss afflicts 466 million people.   2\u00a0 There are no approved drugs to […]","og_url":"https:\/\/www.cilcare.com\/jp\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/","og_site_name":"Cilcare","article_published_time":"2019-03-04T08:59:23+00:00","og_image":[{"url":"http:\/\/cilcare.com\/wp-content\/uploads\/2019\/03\/Image1-300x63.png","type":"","width":"","height":""}],"author":"CILcare","twitter_card":"summary_large_image","twitter_misc":{"\u57f7\u7b46\u8005":"CILcare","\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"3\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/","url":"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/","name":"World Hearing Day : Not A Single Drug Is Approved to Treat Hearing Loss, but Now There Is Hope - Cilcare","isPartOf":{"@id":"https:\/\/www.cilcare.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/#primaryimage"},"image":{"@id":"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/#primaryimage"},"thumbnailUrl":"http:\/\/cilcare.com\/wp-content\/uploads\/2019\/03\/Image1-300x63.png","datePublished":"2019-03-04T08:59:23+00:00","author":{"@id":"https:\/\/www.cilcare.com\/#\/schema\/person\/71c4c9a5956da88e9a9de08ad23b27ac"},"breadcrumb":{"@id":"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/"]}]},{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/#primaryimage","url":"http:\/\/cilcare.com\/wp-content\/uploads\/2019\/03\/Image1-300x63.png","contentUrl":"http:\/\/cilcare.com\/wp-content\/uploads\/2019\/03\/Image1-300x63.png"},{"@type":"BreadcrumbList","@id":"https:\/\/www.cilcare.com\/2019\/03\/04\/not-a-single-drug-is-approved-to-treat-hearing-loss-but-now-there-is-hope\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.cilcare.com\/"},{"@type":"ListItem","position":2,"name":"World Hearing Day : Not A Single Drug Is Approved to Treat Hearing Loss, but Now There Is Hope"}]},{"@type":"WebSite","@id":"https:\/\/www.cilcare.com\/#website","url":"https:\/\/www.cilcare.com\/","name":"Cilcare","description":"Making hearing a priority","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.cilcare.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ja"},{"@type":"Person","@id":"https:\/\/www.cilcare.com\/#\/schema\/person\/71c4c9a5956da88e9a9de08ad23b27ac","name":"CILcare","image":{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/www.cilcare.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/4bc8be812ab5693ac188aed8222fa384249de7201f47b7b8db392d1474d732de?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/4bc8be812ab5693ac188aed8222fa384249de7201f47b7b8db392d1474d732de?s=96&d=mm&r=g","caption":"CILcare"}}]}},"_links":{"self":[{"href":"https:\/\/www.cilcare.com\/jp\/wp-json\/wp\/v2\/posts\/3257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cilcare.com\/jp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cilcare.com\/jp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cilcare.com\/jp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cilcare.com\/jp\/wp-json\/wp\/v2\/comments?post=3257"}],"version-history":[{"count":0,"href":"https:\/\/www.cilcare.com\/jp\/wp-json\/wp\/v2\/posts\/3257\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.cilcare.com\/jp\/wp-json\/wp\/v2\/media?parent=3257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cilcare.com\/jp\/wp-json\/wp\/v2\/categories?post=3257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cilcare.com\/jp\/wp-json\/wp\/v2\/tags?post=3257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}