Scientific corner

Read publications and scientific journal articles related to inner ear disorders like tinnitus, hearing loss, and otitis. Those publications and articles are publics. You can learn more about our services or CILcare’s team actualities.

Through these articles, several approaches to hearing disorders are discussed. The work of our team of scientists and the scientific literature highlight themes on these disorders, including pharmaceutical approaches for the management of inner ear disorders or biomarkers for Hearing Dysfunction.

CILcare’s publications

New Automatic and Robust Measures to Evaluate Hearing Loss and Tinnitus in Preclinical Models

Laboulais A, Malmström S, Dejean C, Cardoso M, Le Meur T, Almeida L, Goze-Bac C, Pucheu S, (2020), Springer Book Chapter 7

The final publication is available at Springer Nature via https://www.springer.com/gp/book/9783030404123

Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise

Gaëlle Naert, Marie-Pierre Pasdelou, Colleen G. Le Prell. The Journal of the Acoustical Society of America (2019) 146:5, 3743-3769.

Myelination of the Auditory Nerve: Functions and Pathology

Sergio Gonzalez-Gonzalez, Chantal Cazevieille. Sci J Research & Rev. 1(3): 2019. SJRR.MS.ID.000513.

Morphological consequences of acoustic trauma on cochlear hair cells and the auditory nerve

Coyat C, Cazevieille C, Baudoux V, Larroze-Chicot P, Caumes B, Gonzalez-Gonzalez S. (2018) Int J Neurosci. 2018 Nov 26:1-16

Biological mechanism of cochlear implant technology in humans

Marie A, Gonzalez-Gonzalez S (2018) J Neurosci Clin Res 3:2.

Noise-induced hearing loss and tinnitus in military personnel

Gonzalez-Gonzalez S. (2018) M J E-Med. 3(1): 027

The Role of Purinergic P2X and P2Y Receptors in Hearing Loss

Gonzalez-Gonzalez S. (2018) J phonet Audiol 4: 136

N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model

A. Marie, J. Meunier, E. Brun, S. Malmström, V. Baudoux, E. Flaszka, G. Naert, F. Roman, S. Cosnier-Pucheu, S. Gonzalez-Gonzalez – 2017 – Aging & Disease

The role of mitochondrial oxidative stress in hearing loss

Gonzalez-Gonzalez S. (2017) Neurological Disorders and Therapeutics 1(4): 1-5

Senescence-accelerated mouse prone 8 (SAMP8) as a model of age-related hearing loss

A. Marie, P. Larroze-Chicot, S. Cosnier-Pucheu, S. Gonzalez-Gonzalez – 2017 – Neuroscience Letters

Current grant calls for application

Medicines Discovery Catapult & We Share - Funding for early-stage patient-focused medicine discovery startups (Hearing loss & Tinnitus)
Ray Charles Foundation Grants
US Department of Defense Hearing Restoration Research Program - Anticipated Funding Opportunities (FY2021)
Capita Foundation Auditory Research (CFAR) Grant
RNID - Flexi Grant Scheme For Hearing Research
Defense Health Program Department of Defense Hearing Restoration Research Program (HRRP) - Anticipated Funding Opportunities for FY21
NIDCD Clinical Research Center Grant (P50 Clinical Trial Optional)
NIDCD Hearing Healthcare for Adults: Improving Access and Affordability (R21/R33 Clinical Trials Optional)
NIDCD Research Career Enhancement Award for Established Investigators - Acquisition of New Research Skills to Answer Questions Relevant to the Hearing, Balance, Smell, Taste, Voice, Speech and Language Sciences (K18 Independent Basic Experimental Studies with Humans Required)
American Hearing Research Foundation - Investigation of the Causes, Diagnosis, or Treatment of Meniere’s Disease Relating to the Hearing or Balance Functions of the Ear Grant
American Hearing Research Foundation - Causes of Sudden Hearing Loss Grant
American Hearing Research Foundation - Hearing & Balance Disorders of the Inner Ear & Related Topics Grant
Hearing Health Foundation's Emerging Research Grants Program (ERG)
RESEARCH FUND OF THE AMERICAN OTOLOGICAL SOCIETY
American Hearing Research Foundation: The 2020 Grant Application Period
Translational Research Initiative for Hearing Grant. RNID and Fondation Pour l’Audition
BROAD AGENCY ANNOUNCEMENT (BAA) for Extramural Biomedical Research and Development. USAMRAA
Hearing Health Fondation: GROUNDBREAKING RESEARCH PROGRAMS
Fondation pour l'audition: Current Funding Announcement
RNID Research Grants

CILcare’s scientific posters

23Na MRI, A New Quantitative Method For The Detection of Tinnitus In An Animal Model
Cochlear Implant : Mini Swine or Sheep? Such a Tricky Choice
The antioxidant N-Acetyl-Cysteine (NAC) as a pharmacological candidates for age-related hearing loss
Comparison of salicylate and noise-induced tinnitus rat models

Latest scientific literature

A Narrative Review of Pharmacologic Treatments for COVID-19: Safety Considerations and Ototoxicity

Christine Little, BA & Maura K. Cosetti, MD, 2021

Systemic application of honokiol prevents cisplatin ototoxicity without compromising its antitumor effect

X. Tan, et al., 2020

 
Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids

C.R. Cederroth, et al., 2019

 
Gene therapy for hearing loss

Ryotaro Omichi, Seiji B Shibata, Cynthia C Morton, Richard J H Smith, 2019

Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models

Wang et al., 2019

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

 Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J, et al. (2019)

Is COPD associated with alterations in hearing? A systematic review and meta-analysis

Bayat et al, 2019

Association of Tinnitus and Other Cochlear Disorders With a History of Migraines

Juen-Haur Hwang, MD, PhD; Shiang-Jiun Tsai; Tien-Chen Liu, PhD; Yi-Chun Chen, MD; Jen-Tsung Lai, MD, 2018

Association of Cardiovascular Comorbidities With Hearing Loss in the Older Old

Kapil Wattamwar, MD; Z. Jason Qian, MD; Jenna Otter, MD; et al, 2018

Intracochlear drug delivery systems: a novel approach whose time has come

M. Peppi, A. Marie, C. Belline, & J. T. Borenstein (2018) Expert Opinion on Drug Delivery, 15:4, 319-324

Innovative pharmaceutical approaches for the management of inner ear disorders

UM Musazzi, S Franzé, F Cilurzo – 2017 – Drug Delivery and Translational Research

Biomarkers for Hearing Dysfunction: Facts and Outlook

L Rüttiger, U Zimmermann, M Knipper – 2017 – ORL

Transient auditory nerve demyelination as a new mechanism for hidden hearing loss

Guoqiang Wan & Gabriel Corfas, DOI: 10.1038/ncomms14487

Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms

M. Charles Liberman a, b, Sharon G. Kujawa

Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development?

Fei Zheng, Jian Zuo

Cellular Mechanism of noise-induced hearing loss

A. Kurabi et al. – 2 December 2016 – Hearing Research

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial

D. R. Freyer et al., The Lancet Oncology, 30 November 2016, DOI: http://dx.doi.org/10.1016/S1470-2045(16)30625-8

Auditory Neuropathy – neural and synaptic mechanism

Moser & Starr, Nature Review, March 2016, doi:10.1038/nrneurol.2016.10

A comprehensive map of molecular drug targets

R. Santoset al., Nature Reviews Drug Discovery, 02 December 2016, doi:10.1038/nrd.2016.230

Can Animal Models Contribute to Understanding Tinnitus Heterogeneity in Humans?

Jos J. Eggermont, Frontiers in Aging Neurosciences, REVIEW, 14 November 2016, doi: 10.3389/fnagi.2016.00265

First hearing-disorder drugs stumble Clinical trial failures of two drugs for hearing loss and tinnitus underscore pitfalls for a nascent area of drug development, but lessons learned may help in navigating the uncharted path to approval

K. Kingwell, Nature Reviews Drug Discovery, 3 Nov 2016; doi:10.1038/nrd.2016.222

Glutamate receptor antagonists for tinnitus

Imsuwansri T, et al., Cochrane Database of Systematic Reviews 2016, Issue 10. Art. No.: CD012391, DOI: 10.1002/14651858.CD012391.

Role of antioxidants in prevention of age-related hearing loss: a review of literature

Elham Tavanai E., Mohammadkhani G., November 2016, Eur Arch Otorhinolaryngol, DOI 10.1007/s00405-016-4378-6