inner ear PK studies

Whatever the route of administration, the drug candidate for hearing loss or tinnitus has to reach its target, the inner ear, at the desired concentration. Cilcare’s PK studies allow the assessment of the bioavailability of the candidate in the inner ear, to determine its kinetic profile, and to estimate the best time-point and concentration for dosing in a subsequent efficacy study:

• Route of administration: local (transtympanic, intrabullar, intracochlear, round window niche) and systemic (PO, IP, IV, SC, IM)
• Kinetics after single (injection or infusion), or repeated administration
• Samplings: inner ear fluid, tympanic bulla, cerebrospinal fluid (CSF), different brain structures, blood & plasma
• Bioanalytical data on biological samples*:
  • Exploratory LC-MS/MS analysis (small molecules)
  • ELISA assays, commercial or customized
  • Expertise in the processing of inner ear fluid & tympanic bulla tissue

*Performed by Cilcare’s partners