in vivo models
Uniquely specialized in the field of hearing disorders and associated diseases, Cilcare provides a comprehensive range of in vivo studies for preclinical research with a strong translational focus. Our dedicated efforts in this field are geared towards driving innovation and progress in the diagnosis and treatment of hearing-related conditions.
in vivo assay in Zebrafish
Zebrafish provide a valuable model for assessing ototoxicity, evaluating otoprotection, and conducting large-scale compound screenings. Zebrafish produce an ideal model due to their similarities with humans (over 85% of genetic homology), rapid development, and optical transparency.
Zebrafish present mechanosensory organs called neuromasts, which detect vibrations in the surrounding environment at frequencies from 50 to 200 Hz. Hair cells in zebrafish neuromasts are similar in structure and function to the inner ear hair cells in mammals. They can easily be visualized in vivo in the optically clear embryo by staining with DASPEI.
Zebrafish model of cisplatin-induced ototoxicity: Reduced numbers of neuromast hair cells in cisplatin-treated zebrafish
Service offered in partnership with Biobide.
Discover our in vitro model and our cochlear explant model.
rodent & larges species
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