PK & DistributionBioanalysisVectors & gene therapy distributionBiomarker studies
Tinnitus detectionGPIAS & PPIHyperacusis
TranstympanicIntracochlearSystemic
Inner ear surgeryCochlear implantationBrain Electrode implantationOther otic surgery
In vitro on Otic cell lineEx vivo on Cochlear explantsIn vivo in Zebrafish
Formulation for otic delivery
Noise-induced hearing lossSynaptopathyCisplatin-induced ototoxicityAntibiotic-induced ototoxicityOuabain-induced auditory neuropathySalicylate-induced tinnitusOther disease & transgenic modelsRodent & large species
Auditory efficacy studiesAuditory tolerance & safety studiesAuditory phenotyping studiesGLP Ototoxicity studies / GLP Toxicology & Toxicokinetics
Small molecules, peptides, antibodies, large moleculesGene & cell therapiesCochlear implants, implantable devices, drug-eluting electrodes
ABRDPOAEWave I to V analysisCAP & unicellular electrophysiology
OtoscopyTympanometryGross middle ear assessment
Histology of the earCytocochleogramHistology of other organsMicroscopy & imaging
BiochemistryMolecular biology
OUR MISSIONS
IN VITRO / EX VIVO / IN VIVO EFFICACY
FORMULATION & DISTRIBUTION
OTOTOXICITY
CLINICAL AUDITORY BIOMARKER
In vitro on Otic cell lineEx vivo on Cochlear explants
Zebrasfish, Rodents & Large speciesNoise-induced hearing lossSynaptopathyCisplatin-induced ototoxicityAntibiotic-induced ototoxicityOuabain-induced auditory neuropathySalicylate-induced tinnitusOther diseases & transgenic models
OtoscopyABRWave I to V analysisDPOAETympanometryTinnitus detectionGPIAS & PPIHyperacusisCAP & unicellular electrophysiologyMolecular Biology & BiochemistryPreclinical biomarkersAuditory phenotyping
Gross middle ear assessmentHistology of the earCytocochleogramHistology of other organsMicroscopy & imaging
Inner ear surgeryCochlear implantationBrain Electrode implantationOther otic surgeries
Middle earIntracochlearSystemic
This infographic allows you to discover to what extent hearing loss is linked to other health conditions and what are important risk factors.